View the Full Spectrum for FREE! Incompatible with strong oxidizing agents. EC number: 205-398-1 | CAS number: 140-10-3 . Int J Cancer. Its biosynthesis involves the action of the enzyme phenylalanine ammonia-lyase (PAL) on phenylalanine.[6]. Cinnamic acid: a natural product with potential use in cancer intervention. [4] It is also found in shea butter. The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. The three samples can be run simultaneously in the DigiMelt (use temperature range of ~110-140 oC). The oldest commercially used route to cinnamic acid involves the Perkin reaction, which is given in the following scheme[5], Cinnamic acid is used in flavorings, synthetic indigo, and certain pharmaceuticals. 1995 Jul 28;62(3):345-50. Description. trans- Cinnamic acid is more stable and has a melting point of 133°C, and a boiling point of 300°C. Take the melting point of pure urea and cinnamic acid. It is found in Cinnamomum cassia. A major use is as a precursor to produce methyl cinnamate, ethyl cinnamate, and benzyl cinnamate for the perfume industry. Cinnamic acid, phen yl ester. Benzenepropanoic acid, a,b-dibromo-, (aR,bS)-rel-. The experimentally derived values used to corroborate calibration of the Melt Station fit within parameters. Hazard Statement: Causes mild skin irritation. Cinnamic acid and urea melt at 133 C. The melting point of an unknown is found to be 133C. Cinnamic acids play key roles in the formation of other more complex phenolic compounds. 1995 Jul 28;62(3):345-50. MDL number MFCD00004369. : 103-26-4 Formula: C10H10O2 Molecular Weight: 162.19 Melting point:: 33.5-36 degrees Celsius Boiling point: 260-262 degrees Celsius Density: 1.092（g/mL,20/4oC） Flash point… Boiling Point:321.5 °C at 760 mmHg. Briefly, 5 X104 cells are plated in each well of a 24-well plate, allowed to attach overnight, and treated with compounds (e.g., Cinnamic acid: 2.5, 5, 10, 20, 30 mM) the following day. Cinnamaldehyde, or 3-phenylprop-2-enal to use its IUPAC name, is a member of the class of compounds known as cinnamaldehydes. Articles of Cinnamic acid are included as well. Guidechem provides trans-Cinnamic acid chemical database query, including CAS registy number 140-10-3, trans-Cinnamic acid MSDS (Material Safety Data Sheet), nature, English name, manufacturer, function/use, molecular weight, density, boiling point, melting point, structural formula, etc. trans-cinnamic acid. This give each a range of 0.5°C. [5], Cinnamic acid is a central intermediate in the biosynthesis of a myriad of natural products including lignols (precursors to lignin and lignocellulose), flavonoids, isoflavonoids, coumarins, aurones, stilbenes, catechin, and phenylpropanoids. The cinnamic acid is soluble in dichloromethane at room temperature and thus before the bromine addition the reaction vessel holds a colourless solution. Cinnamic acid was first synthesized by the base-catalysed condensation of acetyl chloride and benzaldehyde, followed by hydrolysis of the acid chloride product. MSDS/SDS Database Search | There are several enantiomers of 2,3-dibromo-3-phenylpropanoic acid, they all have a molecular weight of 308 g/mol (Molecular Weight: 307.96662 to be specific).The (2R, 3S) and (2S, 3R) have a melting point of 202-204 degrees Celsius. Treatment with 5 mM Cinnamic acid results in 75-95% loss of invasiveness[1]. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. [1]. It can also be prepared by oxidation of cinnamaldehyde, condensation of benzal chloride and sodium acetate (followed by acid hydrolysis), and the Perkin reaction. Disclaimer, Copyright © 2018 ChemSrc All Rights Reserved. In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. [7] Another way of preparing cinnamic acid is by the Knoevenagel condensation reaction. Molecular Weight: 307.969. Molecular Formula:C9H8BR2O2. The full spectrum can only be viewed using a FREE account. Trans-cinnamic acid (E-3-phenyl-2-propanoic acid) has a molecular weight of 148 g/mol and a melting point of 133 degrees Celsius. Service | 140 -10 -3 205 -398 -1 - 4. Molecular Weight 148.16 . It exists as both a cis and a trans isomer, although the latter is more common. Melting point of trans-cinnamic acid: 133-134 0C. Viability is determined by Trypan-blue exclusion assay[1]. PubChem Substance ID … Biologically Active Compounds | The cell lines used, established from human malignant tumors, are A549 (lung cancer); PC3(M), Du145, and LNCaP (prostate cancer); A172, U251 (glioblastoma); and SKMEL28, A375(M), 1011 (melanoma). It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. acetic acid, benzylidene-, acrylic acid, 3-phenyl-, 3-phenylacrylic acid 3-phenyl-2-propenoic acid formic acid, styryl-, benzylideneacetic acid Technique KBr WAFER If you are using one of the small black apparati, the instructions are contained on the front of the apparatus. After 3 days of continuous treatment with Cinnamic acid, a dose-dependent loss of invasive capacity in 3 tested tumor lines is observed. Chemsrc provides trans-Cinnamic acid(CAS#:140-10-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. [5] In 1890, Rainer Ludwig Claisen described the synthesis of ethyl cinnamate via the reaction of ethyl acetate with benzaldehyde in the presence of sodium as base. It has a role as a plant metabolite. Int J Cancer. Shanghai Jizhi Biochemical Technology Co., Ltd. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. [4] Cinnamic acid is a precursor to the sweetener aspartame via enzyme-catalysed amination to give phenylalanine. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Cinnamic acid has a honey-like odor;[2] it and its more volatile ethyl ester (ethyl cinnamate) are flavor components in the essential oil of cinnamon, in which related cinnamaldehyde is the major constituent. Buying Leads | PropertiesSafety and HandlingMSDSComputational chemical data29 Suppliers. CAS No:31357-31-0. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. [4] Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Liu L, et al. Pentane boils at about a third of the temperature of boiling water (see Table A below), making it easier to experimentally observe the vapor point. If inhaled Phenyl (2E)-3-pheny lacrylate [ACD/IUPAC Name] phenyl (2E)-3-pheny lprop-2-enoate. Find chemicals information trans-Cinnamic acid at guidechem, professional and easy to use. 2-Fluorocinnamic acid is a pharmaceutical intermediate in the form of white crystals. Product Classification | It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. Cinnamic acid has the formula C6H5CHCHCOOH and is an odorless white crystalline acid, which is slightly soluble in water. Dispose of this material and its container to hazardous or special waste collection point Cinnamaldehyde, or 3-phenylprop-2-enal to use its IUPAC name, is a member of the class of compounds known as cinnamaldehydes. There are three mixtures (1:3, 1:1, 3:1), one group only need to do . Boiling Point: 265.0±0.0 °C at 760 mmHg Vapour Pressure: 0.0±0.5 mmHg at 25°C Enthalpy of Vaporization: 53.1±3.0 kJ/mol Flash Point: 189.5±9.6 °C Index of Refraction: Within 5 days of treatment with 5 mM Cinnamic acid, melanoma 1011 cells appear enlarged with a markedly increased cytoplasm-to-nuclear ratio and well organized cytoskeleton, developed long dendritic processes and became highly melanotic. Melting point of unknown: 133-133.5 0C. Selling Leads | Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. one. A. Calibration of the thermometer using naphthalene (80-82°C) B. EC -No. Beilstein/REAXYS Number 1905952 . Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. Growth rates are determined by cell counting. Cinnamic Acid Urea Pentane. Melting Points. Synonym: 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapinic acid Empirical Formula (Hill Notation): C 11 H 12 O 5 Molecular Weight: 224.21 Cinnamic aldehyde. trans-Cinnamic acid and cis-Cinnamic acid . And it is an oily yellow liquid … If not, what further tests would you perform? The acid is used to produce flavorings, synthetic indigo, pharmaceuticals, perfumes, and aspartame sweeteners. Cinnamic acid - cas 140-10-3, synthesis, structure, density, melting point, boiling point It is obtained from oil of cinnamon, or from balsams such as storax. Linear Formula C 6 H 5 CH=CHCOOH . Analysis: Boiling Point of Pentane. Display Name: trans-cinnamic acid EC Number: 205-398-1 EC Name: trans-cinnamic acid CAS Number: 140-10-3 Molecular formula: C9H8O2 IUPAC Name: (2E)-3-phenylprop-2-enoic acid Cells are grown for 3 days at 37°C in the presence or absence of the drug, then detached with trypsin/EDTA and counted in a Coulter counter. Precautionary Statement:-PREVENTION- Observe good industrial hygiene practices.-RESPONSE- If skin irritation occurs: Get medical advice/attention.-STORAGE- Store away from incompatible materials. Cinnamic Acid EC50 Daphnia magna (Water flea) (mg/l - 48hr): No data available Section 13: Disposal considerations General information Dispose of in compliance with all local and national regulations. Articles of Cinnamic acid are included as well. Melting point of unknown mixed with Melting point of unknown: 133-133.5 0C. Bromination of Cinnamic acid Supplementary Material Experimental notes This experiment aims at the preparation of the 2,3-dibromo-3-phenylpropanoic acid from cinnamic acid by bromine addition. Determine the melting points of pure samples of cinnamic acid and urea as well as a 50:50 mixture of the two, and record the data in your lab notebook. Cinnamic Acid Cinnamic acid is a naturally-occurring, organic, unsaturated carboxylic acid that exists as both cis and trans isomers. Cinnamic aldehyde. It has a melting point of 133 degrees and a boiling point of 300 degrees.